CHARLES A HORWITZ MD

	CHARLES A HORWITZ, M.D. Abbott Northwestern Hospital Laboratory 800 E 28th St Minneapolis, MN 55407 (612) 863-4670 fax (612) 863-8375 PROFESSIONAL TRAINING AND EXPERIENCE Staff Pathologist, Hospital Pathology Associates, St Paul, MN, 1995 - present Professor; Department of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN, 1982-present Staff Pathologist, Associated Pathologists, Minneapolis, MN, 1991-1994 Staff Pathologist, Metropolitan-Mt Sinai Hospital, Minneapolis, MN, 1968-1991 EDUCATION Research Fellow, University of California, San Francisco, CA, 1966-1968 Surgical Pathology Fellow, Memorial Hospital, New York, NY, 1965-1966 Teaching Fellow, Harvard Medical School, Cambridge, MA, 1963-1965 Pathology Resident, Boston City Hospital, Boston, MA, 1963-1965 General Medical Officer, United States Public Health Service Indian Hospitals, Talihini and Tahlequah, OK, 1960-1962 Intern, Mount Sinai Hospital, Milwaukee, WI, 1959-1960 M.D., University of Wisconsin, Madison, WI,1959 HONORS & AWARDS Member, American Board of Pathology Test Committee for Immunopathology, 1991- present Member, College of American Pathologists Diagnostic Immunology Resource Committee, 1990-present Chief of Staff, Metropolitan-Mount Sinai Medical Center, 1989 Member, Editorial Board, American Journal of Clinical Pathology, 1989-present Member, American Society of Clinical Pathologists Council on Immunopathology, 1984-1990 (Editor of Check Sample Program in Immunopathology) Director, University of Minnesota Laboratory Medicine Course LAMP 5-187, 1984-1991 (Associates, Theresa A. Steeper, M.D., and Susan A. Fuhrman, M.D., co-recipients of Distinguished Teaching Award, Minnesota Medical Foundation, 1986, 1988) Distinguished Teaching Award, Minnesota Medical Foundation, 1977, 1978 (Co-recipients Patrick C. J. Ward, M.D., and M. Desmond Burke, M.D.) Award Recipient, New York State Residents Research Competition, 1966 President, New England Pathology Residents Association, 1964-1965 PROFESSIONAL CERTIFICATIONS Anatomic Pathology - 1966 Clinical Pathology - 1968 Immunopathology - 1983 LICENSURE State of Minnesota - 1968 PROFESSIONAL AFFILIATIONS American Society of Cytopathology Minnesota Society of Cytology Papanicolaou Society of Cytopathology College of American Pathologists American Society of Clinical Pathologists Hennepin County Medical Society Twin City Society of Pathologists PUBLICATIONS Benitez L, Horwitz CA, and Fahimi D. Histochemical localization of lactate dehydrogenase isoenzymes. J Histochem Cytochem 1966;14: 763-764. Horwitz CA, Benitez L, and Braz M. The effect of coenzyme Q on the histochemical succinic tetrazolium reductase reaction: A histochemical study. J Histochem Cytochem 1967; 15:216-224. Rosenau Wand Horwitz CA. Graft rejection in paternal to F hybrid and reciprocal hybrid grafts indicating a histocompatibility on the mouse X chromosome. Lab Invest 1968; 18:298-303 Horwitz CA and Sinykin M: Pregnancy testing. Minn Med 1970; 53:311-314. Horwitz CA, Polesky H, Odenbrett P, Gronli M, Horwitz A, Diamond R, and Ward PCJ. Clinical and immunologic study of a direct agglutination test for pregnancy (mechanisms of interference including prozoning and circulating macroglobulins). Am J Obstet Gynecol 1971;111:808-819. Horwitz CA and Ward PCJ. Disseminated intravascular coagulation, nonbacterial thrombotic endocarditis and adult pulmonary hyaline membranes --an interrelated triad? Report of a case following small bowel resection for a strangulated inguinal hernia. Am J Med 1971 ;51 :272-279. Horwitz CA, Garmezy L, Lyon F, Hensley M, and Burke MD. A comparative study of five immunologic pregnancy tests: An analysis of 1 ,863 cases. Am J Clin Pathol 1972;58:305-313. Horwitz CA, Sinykin M, Hill D, Jerome E, and Burke MD. Evaluation of a new pregnancy test: Pregnosticon Dri-Dot. Obstet Gynecol 1972;40:563-566. Horwitz CA, Myers WPL, and Foote F Jr. Secondary malignant tumors of the para-thyroid glands: Report of two cases with associated hypoparathyriodism. Am J Med 1972; 52: 797 -808. Horwitz CA, Maslansky R, Waldinger R, Cabrera H, and Ward PCJ. Effect of Methadone on human pregnancy tests. J Reprod FertiI1973; 33: 489-493. Horwitz CA, Jerome E, Diamond R, and Ward PCJ. Evaluation of a latex tube agglutination-inhibition pregnancy test: An analysis of 1,776 specimens. Am J Obstet Gynecol 1973; 116:626-632. Horwitz CA, Polesky H, Stillman T, Ward PCJ, Henle G, and Henle W. Persistent hemagglutination for infectious mononucleosis in rheumatoid arthritis. Br Med J 1973; 1: 591-592. o Horwitz CA, Jerome E, Paulson C, Stearns J, Ross R, and Ward PCJ. Evaluation of a latex agglutination-inhibition slide pregnancy test (Pregnosis@). Obstet Gynecol 1974;43:693-696. o Henle W, Henle G, and Horwitz CA. EBV-specific diagnostic tests in infectious mononucleosis. Human PathoI1974; 5: 551-565. o Henle G, Henle W, and Horwitz CA. Antibodies to EBV-associated nuclear antigen in infectious mononucleosis. J Infect Dis 1974; 130: 231-239. o Horwitz CA, Henle W, Henle G, and Schmit H: Clinical evaluation of patients with infectious mononucleosis who developed antibodies to the R component of EBV early antigens (EA). Am J Med 1975; 58:330-338. o Ross R, Horwitz CA, Hager H, Usategue M, Burke MD, and Ward PCJ. Preliminary evaluation of a latex agglutination-inhibition tube test for morphine. Clin Chem 1975; 21: 139-143. o Horwitz CA, Henle W, Henle G, Polesky H, and Ward PCJ. The specificity of heterophil antibodies in patients and healthy donors with no or minimal signs of infectious mononucleosis. Blood 1976; 47: 91-98. o Horwitz CA, Henle W, Henle G, Segal M, Arnold T, Lewis F, Zanick D, and Ward PCJ. Clinical and laboratory confirmation of elderly patients with heterophil-antibody-positive infectious mononucleosis: Report of seven patients, ages 40 to 78. Am J Med 1976; 61: 333-339. o Shapiro S, Segal M, and Horwitz CA. Two primary intracranial tumors of different histological type. Minn Med 1976; 59: 84-89. o Ward PCJ, Harris I, Burke MD, and Horwitz CA. Systemic instruction in interpretive aspects of laboratory medicine. J Med Educ 1976; 51: 648-656. o Horwitz CA, Moulds J, Henle W, Henle G, Polesky H, Balfour H, Schwartz B, and Hoff T. Cold agglutinins in infectious mononucleosis and heterophil-antibody-negative mononucleosis-like syndromes. Blood 1977; 50: 195-202. o Ginsburg CM, Henle W, Henle G, and Horwitz CA. Infectious mononucleosis in children. JAMA 1977; 237: 781-785. o Horwitz CA, Burke MD, Henle W, Henle G, Penn G, and Weinberg D. Late persistence of serum gamma glutamyl transpeptidase (GGTP) activity following mononucleosis: Report of three cases. GastroenteroI1977; 72: 1322-1325. o Horwitz CA, Henle W, Henle G, Polesky H, Balfour H, Siem R, Borken S, and Ward PCJ. Heterophil-negative infectious mononucleosis and mononucleosis-like illnesses: Laboratory confirmation of 43 cases. Am J Med 1977; 63: 947 -957. o Lennette E, Henle G, Henle W, and Horwitz CA. Heterophil antigen in bovine sera detectable by immune adherence hemagglutination with infectious mononucleosis sera. Infect Immunity 1978; 19: 923-927. o Bahna S, Horwitz CA, Fiala M, and Herner D. IgE response in heterophil-negative infectious mononucleosis. J Allergy Clin Immuno 1978; 62: 167-173. o Henle W, Henle G, and Horwitz CA. Infectious mononucleosis. In, Diagnostic Procedures for Viral Rickettsial and Chlamydial Infections (Lennette EH and NJ Schmidt, eds), 5th ed. American Public Health Association, 1979, chapt 14, pp 441-470. o Horwitz CA, Henle W, Henle G, Penn G, Hoffman N, and Ward, PCJ. Persistently falsely positive rapid tests for infectious mononucleosis. Report of five cases with four-six-year follow-up data. Am J Clin Pathol 1979; 72: 807 -811. Laboratory Medicine Series. Postgrad Med, 1978-1981. o Horwitz CA and Lee CY. Pregnancy testing: Immunoassay and radioimmunoassay (I). Postgrad Med 1978; 63(5): 193-200. o Horwitz CA and Lee CY. Pregnancy testing: Radioreceptor assay (II). Postgrad Med 1978; 63(6): 145-151. o Horwitz CA. Laboratory aspects of mononucleosis: Practical approach to diagnosis of infectious mononucleosis. Postgrad Med 1979; 65(6): 179-184. o Horwitz CA, Henle W, and Henle G. Diagnostic aspects of the cytomegalovirus mononucleosis syndrome in previously healthy persons. Postgrad Med 1979; 666(1): 153-160. o Horwitz CA. Autoimmune hemolytic anemia: (1) Warm antibody type. Postgrad Med 1979;666(2):167-174. o Horwitz CA. Autoimmune hemolytic anemia: (2) Drug-induced type. Postgrad Med 1979;66(3): 199-205. o Horwitz CA. Autoimmune hemolytic anemia: (3) Cold antibody type. Postgrad Med 1979;66( 4 ): 189-196. o Horwitz CA. Collagen disease: Laboratory investigation of systemic lupus erythematosus. Postgrad Med 1980; 67(4): 193-200. o Horwitz CA. Collagen disease: Laboratory diagnosis of rheumatic diseases. Postgrad Med 1980;67(5):193-203. o Horwitz CA. Laboratory investigation of syphilis. Postgrad Med 1980; 67: 71-80. o Horwitz CA. A practical approach to disorders of hemostasis. Postgrad Med 1981; 69: 79-93. o Horwitz CA. Blood transfusion therapy. Postgrad Med 1981; 69: 155-164. o Horwitz CA. Laboratory diagnosis of viral hepatitis. Postgrad Med 1981; 70: 105-117. o Ward PCJ, Horwitz CA, and Burke MD. Teaching proper laboratory use to medical students and physicians. In, Clinician and Chemist: The Relationship of the Laboratory to the Physician (Young DS, Uddin D, Nipper H, Hicks J, and JS King, eds). Winston-Salem, NC: American Association for Clinical Chemistry, 1979, chapt V, pp 334-347. o Horwitz CA. Pregnancy tests 1980: Advantages and limitations. Lab Med 1980; 11 (9): 620-624. o Horwitz CA, Burke MD, Grimes P, and Tombers J. Hepatic function studies in EBV- and CMV-mononucleosis: Evaluation of 154 serially studied cases. Clin Chem 1980; 26: 243-246. o Derman R, Corson SL, Horwitz CA, Lau HL, and Soderstrom R: Early diagnosis of pregnancy --a symposium. J Reprod Med 1981; 26(suppl):149-177. o Horwitz CA, Henle W, Henle G, Goldfarb M, Kubic P, Gehrz R, Balfour H, Fleisher G, and Krivit W. Clinical and laboratory evaluation of infants and children with Epstein-Barr virus-induced infectious mononucleosis: Report of 32 patients (aged 10 to 48 months). Blood 1981 ;57:933-938. o Horwitz CA, Henle W, Henle G, Polesky H, and Leonardy J. Spurious rapid I.M. test data in non-I.M. sera: The role of high-titer horse agglutinins. Am J Clin Pathol 1982;78:48-53. o McMonigal K, Horwitz CA, Henle W, Henle G, Lawton J, Polesky H, and Peterson L. Post-perfusion syndrome due to EBV: A report of two cases and a critical review of the literature. Transfusion 1983; 23: 331-335. o Horwitz CA, Henle W, Henle G, et al. Infectious mononucleosis in older patients: Report of 27 cases ages 40-72, including three heterophil-negative cases. Medicine 1983;62:256-262. o Horwitz CA, Henle W, Henle G, and McClain K. Fatal illness in a two-week-old infant: Diagnosis by detection of EBV genomes from a lymph node biopsy. J Pediat 1983;103:752-755. o Snover DC and Horwitz CA. Liver disease in cytomegalovirus mononucleosis: A light microscopical and immunoperoxidase study of six cases. Hepatol 1984; 4: 408-412. o Bahna S, Heiner DC, and Horwitz CA. Sequential changes of immunoglobulin classes and other responses in I.M. Internatl Arch Allergy Appl Immunol1984; 74:1-8. o Horwitz CA, Skradski K, Reece E, et al. Hemolytic anemia in adult patients with spontaneous CMV infections: Report of two cases and evaluation of subclinical hemolysis in CMV mononucleosis. Scand J Hematol 1984;33:35-42. o Horwitz CA. Heterophil-negative, Epstein-Barr-virus-positive infectious mononucleosis. ASCP Check Sample Series, Clinical Immunology #CI-8, 1978, pp 1-7. o Horwitz CA. False-positive rapid I.M. slide tests. ASCP Check Sample Series, Hematology #H82-6 (H-125), November 1982, pp 1-8. o Shacks SJ, Heiner DC, Bahna Sl, and Horwitz CA. Increased serum IgG41evels in acute Epstein-Barr virus mononucleosis. Ann Allergy 1985;54: 284-288. o Horwitz CA, Neiderman JC, and Rapp CE. When symptoms point to mononucleosis. Patient Care 1983;17: 58-74. o Horwitz CA, Henle W, Henle G, et al. long-term serologic follow-up of patients with EBV after recovery from infectious mononucleosis. J Infect Dis 1985; 151: 1150-1155. o Polesky HF and Horwitz CA. Acute transfusion reactions. In, Current Diagnosis (R Conn, ed), 7th ed. Philadelphia: WB Saunders Co, 1985, p 631-633. o Horwitz CA, et al. CMV mononucleosis: Clinical and laboratory features in 82 previously healthy individuals. Medicine 1986; 65: 124-134. o Smith RS, Rhodes GR, Vaughan JH, Horwitz CA, et al. Human antibodies to a synthetic peptide from the EBV nuclear antigen in sera from patients with I.M. J Infect Dis 1986;154:885-889. o Henle W, Henle G, Andersson J, Ernberg 1, Klein G, Horwitz CA, Marklund G, Gymo l, and Wellinder C. Antibody responses to EBV-determined nuclear antigen (EBNA-1 and EBNA-2) in acute and chronic EBV infection. Proc Natl Acad Sci 1987;84:570-574. o Stanley M, Horwitz CA, levinson RM, and Sibley RK. Carcinoid tumors of the middle ear. Am J Clin PathoI1987;87: 592-600. o Fuhrman SA, Gill R, Horwitz CA, Henle W, Henle G, et al. Marked hyper-bilirubinemia in infectious mononucleosis. Analysis of laboratory data in seven cases. Arch Intern Med 987;147:850-853. o Steeper TA, Horwitz CA, Henle W, and Henle G. Selected aspects of acute and chronic infectious mononucleosis and mononucleosis-like illnesses for the practicing allergist. Ann Allergy 1987;59:243-250. o Johnson KM and Horwitz CA. False-positive rapid tests for infectious mononucleosis (solicited manuscript, ASCP Tech Sample Series #C1-4, 1987). o Henry MJ and Horwitz CA. Interesting case of the month. American Society of Cytology: The Cytotechnologist's Bulletin 1987;24:51-52. o Henry MJ, Burton LG, Stanley MW, and Horwitz CA. Application of a modified Diff-Quik stain to find needle aspiration smears. Rapid staining with improved cytologic detail. Acta CytoI1987;31:954-955. o Henry MJ, Horwitz CA, and Stanley MW. Cyto-structural localization of peanut lectin binding in fine needle aspirates of benign and malignant breast lesions. Diag Cytol 1987;3: 311-314. o Stanley MW, Tani EM, Horwitz CA, Tulman S, and Skoog L. Primary spindle cell sarcomas of the breast. Diagnosis by fine needle aspiration. Diag Cytopathol 1988;4:244-249. o Kaye KW and Horwitz CA. Trans-rectal fine needle biopsy of the prostate: Combined histological and cytological technique. J Urol 1988; 139: 1229-1231. o Steeper TA, Horwitz CA, Hanson M, Henle W, et al. Heterophil-negative mononucleosis-like illnesses with atypical lymphocytosis in patients undergoing seroconversions to the human immunodeficiency virus. Am J Clin Pathol 1988;89: 169-174. o Stanley MW, Horwitz CA, Henry M, Burton LG, and Lowhagen T. Basal cell adenoma of the salivary gland: Fine needle differential diagnosis from acinic cell carcinoma. Diag Cytopathol 1988;4: 342-346. o Steeper T, Horwitz CA, Henle W, Henle G, Moore B, Flynn PJ, and Ellis R. Marked thrombocytopenia in EBV-IM. Report of seven cases with platelet counts below 25,000/mm3. West J Med 1989;150: 170-173. o Smith RS, Rhodes G, Geltosky J, Horwitz CA. Antibodies to an Epstein-Barr virus nuclear antigen synthetic peptide in infectious mononucleosis. Report of two cases. Am J Clin Pathol 1989;92:447 -451. o Kaye K and Horwitz CA. Trans-rectal ultrasound-guided prostate biopsies using a new automatic gun. J EndouroI1989;3: 155-161. o Steeper T A, Horwitz CA, et al. Clinical and laboratory findings in patients with mono-like illnesses due to HHV-6. Am J Clin Pathol 1990;93: 776-783. o Stanley M, Burton L, Horwitz CA. Negative images of bacilli and mycobacterial disease --FNA smears from lymph nodes in patients with AIDS. Diag Cytopathol 1990;6:118-121. o Stanley M, Steeper TA, Horwitz CA, Strickler J, Burton L, and Borken S. Fine needle aspirations in lymph nodes in ten patients with acute infectious mononucleosis. Diag Cytopathol 1990;6:323-328. o Strickler JG, Movahed LA, Gajl-Peczalaka KJ, Horwitz CA, Brunning RD, and Weiss LM. Detection of oligoclonal T -cell receptor gene rearrangements in blood lymphocytes of patients with acute infectious mononucleosis. J Clin Invest 1990; 86: 1358-1363. o Rhodes G, Smith RS, Rubin RE, Vaughan J, and Horwitz CA. Identical IgM antibodies recognizing a glycine-alanine epitope are induced during acute infection with EBV and CMV. J Clin Lab Analysis 1990;4: 456-464. o Stanley M, Horwitz CA, Sharer W, Kaye K, and Burton LG. Granulomatous prostatitis: A spectrum including nonspecific, infectious and spindle cell lesions. Diag Cytopathol 1991;7: 508-512. o Stanley MW, Horwitz CA, and Frable WJ. Cellular follicular cysts of the ovary: Fluid cytology mimics malignancy. Diag Cytopathol 1991; 7: 48-52. o Horwitz CA, Krueger GRF, Steeper T A, and Bertram G. HHV-6-induced mononucleosis-like illnesses. In, Human Herpes Virus-6 (Ablashi DV, Krueger GRF, and SZ Salahuddin eds). Amsterdam: Elsevier, 1992, chapt 13, pp 159-174. o Strickler J, Fedeli F, Horwitz CA, et al. Infectious mononucleosis in lymphoid tissue: Histopathologic in-situ hybridization and differential diagnosis. Arch Pathol Lab Med 1993; 117: 269-278. o Horwitz CA and Benecke J. Human herpesvirus-6 (HHV-6) revisited. Am J Clin Pathol 1993;99: 533-535. o Stanley MW, Skoog L, Tani EM, and Horwitz CA. Nodular fasciitis: Spontaneous resolution following diagnosis by fine-needle aspiration. Diag Cytopathol 1993; 9:322-324. o Horwitz CA and Steeper T A. Immunoserology of IM and mononucleosis-related heterophil-negative IM-like illnesses. In, Clinical Laboratory Medicine (McClatchey KD, ed). Baltimore: Williams and Wilkens, 1994, chapt 58, pp 1535-1542. o Horwitz CA, Inampudi S, and Kaye K. Diagnostic difficulties in the interpretation of aspiration material in large renal cysts. Diag Cytopathol 1994; 11: 380-384. o Stanley M and Horwitz CA. Aspiration cytology of lymph nodes in infectious mononucleosis. Check Sample Series, ASCP C95-1 (C251), pp 1-9, 1995. o Stanley M, Horwitz CA, Rollins SD, et al. Basal cell (monomorphic) and minimally pleomorphic adenomas of the salivary glands: Distinction from solid (anaplastic) type of adenoid cystic carcinoma in fine needle aspiration. Am J Clin Pathol 1996; 106: 35-41. o Stanley MW, Horwitz CA, Bardales RH, Stern SJ, and Korourian S. Basal cell carcinoma metastatic to the salivary glands: Differential diagnosis in fine needle aspiration cytology. Diag CytopathoI1997; 16: 247-252. o Horwitz CA and Steeper T A. Epstein-Barr virus and mononucleosis-like illnesses. In Clinical Diagnostic Immunology (Nakamura R and J Folds, eds). Maiden, MA: Blackwell Science Publishers, chapt 40, pp 411-419, 1998. o Krueger GR, Koch B, Rojo J, Horwitz CA, et al. Comparison of seroprevalences of Human herpes virus -6 and -7 in healthy blood donors from nine countries. Vox Sang 1998; 75: 193-197. o Traverse JH, Lesser JR, Flygenring BP, Bracken TH, Olevsky OM, Nicoloff DM, Flavin T, Horwitz CA, and Hauser RG. Epithelioid hemangioendothelioma of the thoracic aorta resulting in aortic obstruction and congestive heart failure. Circulation 1999; 100:564-565. o Lundeen SJ, Horwitz CA, Larson CJ, and Stanley MW. Abnormal cervicovaginal smears due to endometriosis: A continuing problem. Diagnostic Cytopathol2002; 26:35-40. o Stanley MW, Horwitz CA, Trombley B, and Day D. Touch preparations on breast core biopsies. Smears vs. biopsy data on 227 consecutive specimens (abstract; manuscript in preparation).
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