John G. Strickler Jr, M.D.

Pathology Lab 11136

Abbott Northwestern Hospital

800 E 28th St.

Minneapolis, MN  55407-373100

Phone: 612-863-4558

FAX: 612-863-8375

Introductory Note:  I have a long-standing professional interest in diagnostic hematopathology, which I regard as a subspecialty of diagnostic surgical pathology.  During various fellowships, I was fortunate to study with outstanding hematopathologists and surgical pathologists at Stanford University (Ronald Dorfman, Roger Warnke, Richard Kempson) and the University of Minnesota (Richard Brunning, Glauco Frizzera).  My professional experience includes sign-out responsibilities in both hematopathology (lymph nodes and bone marrows) and general surgical pathology at the University of Minnesota (1988-1990) and the Mayo Clinic ( 1990-1999).  I continue to have similar interests and responsibilities in my current position with Hospital Pathology Associates (1999 to current). 

PROFESSIONAL INTERESTS

• Hematopathology

• Surgical Pathology

PROFESSIONAL TRAINING AND EXPERIENCE  

Hospital Pathology Associates, March 1999 to present

• Shareholder Pathologist (March 1999 to present)
• President, Hospital Pathology Associates (January 1, 2001 to present)

Mayo Clinic – Department of Pathology, July 1990 to February 1999

• Assistant Professor of Pathology (July 1990 to June 1992)

• Associate Professor of Pathology (July 1992 to February 1999)

• Senior Associate Consultant in Pathology (July 1990 to June 1993)

• Consultant in Pathology (July 1993 to February 1999)

University of Minnesota Hospital, January 1988 to June 1990

• Assistant Professor of Pathology 

EDUCATION  

College:  College of William and Mary, Williamsburg, Virginia, B.S., 1978

Medical School: University of Virginia, Charlottesville, Virginia, M.D., 1982

Residency: Anatomic Pathology Intern and Resident, Stanford University Medical Center, July 1982 to June 1984

Fellowships: 

• Surgical Pathology Fellow, Stanford University Medical Center, July 1984 to June 1985

• Instructor in Surgical Pathology, Immunodiagnosis Fellow, Stanford University Medical Center, July 1985 to Dec. 1986

• Hematopathology Fellow, University of Minnesota Hospital, Jan. 1987 to Sept. 1987

• Hematopathology Research, Stanford University Medical Center, Oct. 1987 to Dec. 1987

HONORS AND AWARDS  

Edward Coles Merit Scholarship, 1975

Phi Eta Sigma Freshman Honor Society, 1975

Joseph Prentis Merit Scholarship, 1976

Phi Beta Kappa, 1977

Phi Sigma Biology Honor Society, 1977

Phi Sigma Society Award in Biology, 1977

Highest Honors in Biology, 1978

Lord Botetourt Medal (for GPA 4.0, class rank 1 of 786), 1978

Alpha Omega Alpha Honor Medical Society, 1981

James R. Cash Book Prize in Pathology, 1982

Villar-Palasi Memorial Award in Pharmacology, 1982

Teacher of the Year, Department of Pathology, Mayo Clinic, 1997

PROFESSIONAL CERTIFICATIONS

American Board of Pathology, Anatomic Pathology, 1986

LICENSURE

1983                State of California

1988                State of Minnesota

1991                State of Arizona

1991                State of Florida

Society memberships

• United States and Canadian Academy of Pathology (1985)

• Society for Hematopathology (1988)

• American Society of Clinical Pathologists (1988)

• American Society of Hematology (1989)

• Minnesota Society of Pathologists (1990)

• Twin City Society of Pathologists (1992)

• Arthur Purdy Stout Society of Surgical Pathologists (1995)

• European Association for Haematopathology (1995)

• International Society for Cutaneous Lymphomas (1996)

BIBLIOGRAPHY

Peer Reviewed Articles (*primary author is a trainee under the direction of Dr. Strickler)

1.      Wiseman LL, Strickler J: Desmosome frequency: experimental alteration may correlate with differential cell adhesion.  J Cell Sci 49:217-223, 1981. 

2.      Strickler JG, Michie SA, Warnke RA, Dorfman RF: The "syncytial variant" of nodular sclerosing Hodgkin's disease. Am J Surg Pathol 10:470-477, 1986.  

3.      Bernstein JI, Coleman CN, Strickler JG, Dorfman RF, Rosenberg SA: Combined modality therapy for adults with small non-cleaved cell lymphoma (Burkitt and non-Burkitt types). J Clin Oncol  4:847-858, 1986. 

4.      Weiss LM, Strickler JG, Dorfman RF, Horning SJ, Warnke RA, Sklar J: Clonal T-cell populations in angioimmunoblastic lymphadenopathy and angioimmunoblastic lymphadenopathy-like lymphoma. Am J Pathol 122:392-397, 1986. 

5.      Weiss LM, Strickler JG, Hu E, Warnke RA, Sklar J: Immunoglobulin gene rearrangements in Hodgkin's disease. Hum Pathol 17:1009-1014, 1986. 

6.      Wood GS, Strickler JG, Deneau DG, Egbert B, Warnke RA:  Lymphomatoid papulosis expresses immunophenotypes associated with T cell lymphoma but not inflammation.  J Am Acad Dermatol 15:444-458, 1986. 

7.      Wood GS, Strickler JG, Abel EA, Deneau DG, Warnke RA:  Immunohistochemistry of pityriasis lichenoides et varioliformis acuta and pityriasis lichenoides chronica. Evidence for their interrelationship with lymphomatoid papulosis.  J Am Acad Dermatol 16:559-570, 1987.  

8.      Strickler JG, Warnke RA, Weiss LM: Necrosis in lymph nodes.  Pathol Annu, part 2, 22:253-282, 1987.  

9.      Weiss LM, Strickler JG, Warnke RA, Purtilo DT, Sklar J:  Epstein-Barr viral DNA in tissues of Hodgkin's disease.  Am J Pathol 129:86-91, 1987.

10.  Strickler JG, Weiss LM, Copenhaver CM, Bindl J, McDaid R, Buck D, Warnke RA: Monoclonal antibodies reactive in routinely  processed tissue sections of malignant lymphoma, with emphasis on T cell lymphomas. Hum Pathol 18:808-814, 1987.  

11.  Weiss LM, Michie SA, Medeiros LJ, Strickler JG, Garcia CF, Warnke RA: Expression of Tac antigen by non-Hodgkin's lymphomas.  Am J Clin Pathol 88:483-485, 1987.  

12.  Michie SA, Garcia CF, Strickler JG, Dailey MO, Rouse RV, Warnke RA: Expression of the Leu-8 antigen by B-cell lymphomas.  Am J Clin Pathol 88:486-490, 1987. 

13.  Weiss LM, Strickler JG, Medeiros LJ, Gerdes J, Stein H, Warnke RA: Proliferative rates of non-Hodgkin's lymphomas as assessed by Ki-67 antibody. Hum Pathol 18:1155-1159, 1987. 

14.  Strickler JG, Herndier BG, Rouse RV: Immunohistochemical staining in malignant mesotheliomas. Am J Clin Pathol 88:610-614, 1987. 

15.  Strickler JG, Hegstrom J, Thomas MJ, Yousem SA: Myoepithelioma of the lung. Arch Pathol Lab Med 111:1082-1085, 1987.  

16.  Medeiros LJ, Strickler JG, Picker LJ, Gelb AB, Weiss LM, Warnke RA: "Well differentiated" lymphocytic neoplasms.  Immunologic findings correlated with clinical presentation and morphologic features. Am J Pathol 129:523-535, 1987.  

17.  Strickler JG, Audeh MW, Copenhaver CM, Warnke RA:  Immunophenotypic differences between plasmacytoma/multiple myeloma and immunoblastic lymphoma. Cancer 61:1782-1786, 1988.  

18.  Strickler JG, Medeiros LJ, Copenhaver CM, Weiss LM, Warnke RA:  Intermediate lymphocytic lymphoma. An immunophenotypic study with comparison to small lymphocytic lymphoma and diffuse small-cleaved cell lymphoma. Hum Pathol 19:550-554, 1988.  

19.  Strickler JG, Copenhaver CM, Rojas VA, Horning SJ, Warnke RA:  Comparison of "host cell infiltrates" in patients with follicular lymphoma with and without spontaneous regression.  Am J Clin Pathol 90:257-261, 1988. 

20.  Medeiros LJ, Picker LJ, Gelb AB, Strickler JG, Brain SW, Weiss LM, Horning SJ, Warnke RA.  Numbers of host "helper" T-cells and proliferating cells predict survival in diffuse small cell lymphomas.  J Clin Oncol 7:1009-1017, 1989. 

21.  *Peterson CJ, Strickler JG, Gonzalez R, Dehner LP:  Uterus-like mass of the small intestine.  Heterotopia or monodermal teratoma?  Am J Surg Pathol 14:390-394, 1990 

22.  Strickler JG, Parkin JL, Schmidt CM, Hurd DD:  Primary skin malignancy with features suggestive of dendritic reticulum cell differentiation.  Ultrastruct Pathol 14:273-282, 1990. 

23.  Strickler JG, Copenhaver CM:  In situ hybridization in hematopathology.  Am J Clin Pathol 93 (Suppl 1):S44-S48, 1990. 

24.  Strickler JG, Manivel JC, Copenhaver CM, Kubic VL:  Comparison of in situ hybridization and immunohistochemistry for detection of cytomegalovirus and herpes simplex virus.  Hum Pathol 21:443-448, 1990. 

25.  Strickler JG, Schmidt CM, Wick MR:  Immunophenotype of hairy cell leukemia in paraffin sections.  Mod Pathol 3:518-523, 1990. 

26.  Stanley MW, Steeper TA, Horwitz CA, Burton LG, Strickler JG, Borken S:  Fine needle aspiration of lymph nodes in patients with acute infectious mononucleosis.  Diagn Cytopathol 6:323-329, 1990. 

27.  Strickler JG, Movahed LA, Gajl-Peczalska KJ, Horwitz CA, Brunning RD, Weiss LM: Oligoclonal T cell receptor gene rearrangements in blood lymphocytes of patients with acute Epstein-Barr virus-induced infectious mononucleosis.  J Clin Invest 86:1358-1363, 1990. 

28.  Litz CE, Goldfarb AN, Strickler JG, Brunning RD:  Presence of cell lineage-specific hypomethylated sites in the major breakpoint cluster region.  Cancer Res 50:4984-4990, 1990. 

29.  *Nakhleh RE, Manivel JC, Copenhaver CM, Sung JH, Strickler JG: In situ hybridization for the detection of Epstein-Barr virus in central nervous system lymphomas.  Cancer 67:444-448, 1991. 

30.  Wick MR, Swanson PE, LeBoit PE, Strickler JG, Cooper PH:  Lymphoepithelioma-like carcinoma of the skin with adnexal differentiation.  J Cutan Pathol 18:93-102, 1991. 

31.  *Nakhleh RE, Copenhaver CM, Werdin K, McDonald K, Kubo SH, Strickler JG:  Lack of evidence for involvement of Epstein-Barr virus in the development of the "Quilty" lesion of transplanted hearts.  An in situ hybridization study.  J Heart Lung Transplant 10:504-507, 1991. 

32.  Strickler JG, Kurtin PJ:  Mediastinal lymphoma.  Semin Diagn Pathol 8:2-13, 1991. 

33.  *d'Amore ESG, Manivel JC, Gajl-Peczalska KJ, Litz CE, Copenhaver CM, Shapiro RS, Strickler JG:  B-cell lymphoproliferative disorders after bone marrow transplant.  An analysis of 10 cases with emphasis on Epstein-Barr virus detection by in situ hybridization.  Cancer 68:1285-1295, 1991. 

34.  *Singleton TP, Strickler JG:  Clinical and pathologic significance of the c-erbB-2 (HER-2/neu) oncogene.  Pathol Annu, part 1, 27:165-190, 1992. 

35.  Weiss LM, Chen YY, Berry GJ, Strickler JG, Dorfman RF, Warnke RA:  Infrequent detection of Toxoplasma gondii genome in toxoplasmic lymphadenitis.  A polymerase chain reaction study.  Hum Pathol 23:154-158, 1992. 

36.  *Berg LC, Copenhaver CM, Morrison VA, Gruber SA, Dunn DL, Gajl-Peczalska K, Strickler JG:  B-cell lymphoproliferative disorders in solid-organ transplant patients.  Detection of Epstein-Barr virus by in situ hybridization.  Hum Pathol 23:159-163, 1992. 

37.  Strickler JG, Singleton TP, Copenhaver CM, Erice A, Snover DC:  Adenovirus in the gastrointestinal tracts of immunosuppressed patients.  Am J Clin Pathol 97:555-558, 1992. 

38.  *Crary GS, Singleton TP, Neglia JP, Swanson PE, Strickler JG:  Detection of metastatic neuroblastoma in bone marrow biopsy specimens with an antibody to neuron-specific enolase.  Mod Pathol 5:308-311, 1992. 

39.  *Singleton TP, Niehans GA, Gu F, Litz CE, Hagen K, Qiu Q, Kiang DT, Strickler JG:  Detection of c-erbB-2 activation in paraffin-embedded tissue by immunohistochemistry.  Hum Pathol 23:1141-1150, 1992.  

40.  Strickler JG, Amsden TW, Kurtin PJ: Small B-cell lymphoid neoplasms with coexisting T-cell lymphomas.  Am J Clin Pathol 98:424-429, 1992.   

41.  George E, Niehans GA, Swanson PE, Strickler JG, Singleton TP:  Over-expression of the c-erbB-2 oncogene in sarcomas and small round cell tumors of childhood.  An immunohistochemical investigation.  Arch Pathol Lab Med 116:1033-1035, 1992. 

42.  Tazelaar HD, Myers JL, Strickler JG, Colby TV, Duffy J: Tryptophan-induced lung disease. An Immuno-phenotypic, immunofluorescent, and electron microscopic study.  Mod Pathol 6:56-60, 1993.  

43.  *Lazcano O, Speights VO, Strickler JG, Bilbao JE, Becker J, Diaz J:  Combined histochemical stains in the differential diagnosis of Cryptococcus neoformans.  Mod Pathol 6:80-84, 1993. 

44.  Strickler JG, Fedeli F, Horwitz CA, Copenhaver CM, Frizzera G:  Infectious mononucleosis in lymphoid tissue.  Histopathology, in situ hybridization, and differential diagnosis.  Arch Pathol Lab Med 117:269-278, 1993. 

45.  Strickler JG, Rooney MT, d'Amore ESG, Copenhaver CM, Roche PC: Detection of Epstein-Barr virus by in situ hybridization with a commercially available biotinylated oligonucleotide probe.  Mod Pathol 6:208-211, 1993.  

46.  Fairbanks RK, Bonner JA, Inwards CY, Strickler JG, Habermann TM, Unni KK, Su J: Treatment of stage IE primary lymphoma of bone. Int J Radiat Oncol Biol Phys 28:363-372, 1994.  

47.  *Wat PJ, Strickler JG, Myers JL, Nordstrom MR: Herpes simplex infection causing acute necrotizing tonsillitis.  Mayo Clin Proc 69:269-271, 1994.

48.  *Singleton TP, Perrone T, Oakley G, Niehans GA, Carson L, Cha SS, Strickler JG: Activation of c-erbB-2 and prognosis in ovarian carcinoma: comparison with histologic type, grade, and stage.  Cancer 73:1460-1466, 1994. 

49.  Behrns KE, Sarr MG, Strickler JG: Pancreatic lymphoma: is it a surgical disease?  Pancreas 9:662-667, 1994.  

50.  Strickler JG, Meneses MF, Habermann TM, Ilstrup DM, Earle JD, McDonald TJ, Chang KL, Weiss LM: "Polymorphic reticulosis": a reappraisal.  Hum Pathol 25:659-665, 1994.  

51.  Barksdale SK, Perniciaro C, Halling KC, Strickler JG: Granuloma annulare in patients with malignant lymphoma: clinicopathologic study of thirteen new cases.  J Am Acad Dermatol 31:42-48, 1994.  

52.  Strickler JG, Zheng J, Shu Q, Burgart LJ, Alberts SR, Shibata D: p53 mutations and microsatellite instability in sporadic gastric cancer: when guardians fail.  Cancer Res 54:4750-4755, 1994.  

53.  Weiss LM, Arber DA, Strickler JG: Nasal T cell lymphoma.  Ann Oncol 5 (Suppl 1): S39-S42, 1994.  

54.  Walker RC, Marshall WF, Strickler JG, Wiesner RH, Velosa JA, Habermann TM, McGregor CG, Paya CV: Pretransplant assessment of the risk of lymphoproliferative disorder. Clin Infect Dis 20:1346-1353, 1995.  

55.  Walker RC, Paya CV, Marshall WF, Strickler JG, Wiesner RH, Velosa JA, Habermann TM, Daly RC, McGregor CGA:  Pretransplantation seronegative Epstein-Barr virus status is the primary risk factor for post-transplantation lymphoproliferative disorder in adult heart, lung, and other solid organ transplantations. J Heart Lung Transplant 14:214-220, 1995. 

56.  Burgart LJ, Zheng J, Shu Q, Strickler JG, Shibata D: Somatic mitochondrial mutation in gastric cancer.  Am J Pathol 147:1105-1111, 1995.  

57.  Myers JL, Kurtin PJ, Katzenstein AA, Tazelaar HD, Colby TV, Strickler JG, Lloyd RV, Isaacson PG:  Lymphomatoid granulomatosis: evidence of Immuno-phenotypic diversity and relationship to Epstein-Barr virus infection.  Am J Surg Pathol 19:1300-1312, 1995. 

58.  Durr ED, Bonner JA, Strickler JG, Martenson JA, Chen MG, Habermann TM, Donohue JH, Earle JD, Grill JP:  Management of stage IE primary gastric lymphoma.  Acta Haematol 94:59-68, 1995.  

59.  Davison SP, Habermann TM, Strickler JG, DeRemee RA, Earle JD, McDonald TJ:  Nasal and nasopharyngeal angio-centric T-cell lymphomas. Laryngoscope 106:139-143, 1996. 

60.  *Salomao DR, Nascimento AG, Lloyd RV, Chen MG, Habermann TM, Strickler JG: Lymphoma in soft tissue: a clinicopathologic study of 19 cases.  Hum Pathol 27:253-257, 1996. 

61.  Badley AD, Portela DF, Patel R, Kyle RA, Habermann TM, Strickler JG, Ilstrup DM, Wiesner RH, de Groen P, Walker RC, Paya CV:  Development of monoclonal gammopathy precedes the development of EBV-induced post-transplant lymphoproliferative disorder.  Liver Transplantation and Surgery 2:375-382, 1996. 

62.  Arber DA, Strickler JG, Weiss LM:  Splenic mesothelial cysts mimicking lymphangiomas.  Am J Surg Pathol 21:334-338, 1997. 

63.  Arber DA, Strickler JG, Chen YY, Weiss LM:  Splenic vascular tumors. A histologic, Immuno-phenotypic, and virologic study.  Am J Surg Pathol 21:827-835, 1997.  

64.  Fonseca R, Tefferi A, Strickler JG:  Follicular dendritic cell sarcoma mimicking diffuse large cell lymphoma. A case report.  Am J Hematol 55:148-155, 1997. 

65.  Braeuninger A, Kuppers R, Strickler JG, Wacker HH, Rajewsky K, Hansmann ML:  Hodgkin and Reed-Sternberg cells in lymphocyte predominant Hodgkin’s disease represent clonal populations of germinal center-derived tumor B-cells.      Proc Natl Acad Sci USA 94:9337-9342, 1997 (correction appeared in Proc Natl Acad Sci USA 94:14211, 1997). 

66.  Levy NT, Young WF, Habermann TM, Strickler JG, Carney JA, Stanson AW: Adrenal insufficiency as a manifestation of disseminated non-Hodgkin’s lymphoma.  Mayo Clin Proc 72:818-822, 1997. 

67.  Ansell SM, Habermann TM, Hoyer JD, Strickler JG, Chen MG, McDonald TJ:  Primary laryngeal lymphoma.  Laryngoscope 107:1502-1506, 1997. 

68.  Dockrell DH, Strickler JG, Paya CV: Epstein-Barr virus-induced T cell lymphoma in solid organ transplant recipients.  Clin Infect Dis 26:180-182, 1998. 

69.  Strickler JG, Donohue JH, Porter LE, Habermann TM:  Laparoscopic biopsy for suspected abdominal lymphoma.  Mod Pathol 11:831-836, 1998. 

70.  Chibbar R, Leung K, McCormick S, Ritzkalla K, Strickler JG, Staggs R, Poppema S, Brunning RD, McGlennen RC:  Bcl-1 gene rearrangements in mantle cell lymphoma.  A comprehensive analysis of 110 cases, including B-5 fixed tissue, by polymerase chain reaction and Southern transfer analysis.  Mod Pathol 11:1089-1097, 1998. 

71.  Ostrowski ML, Inwards CY, Strickler JG, Witzig TE, Wenger DE, Unni KK:  Osseous Hodgkin’s disease.  Cancer 85:1166-1178, 1999. 

72.  Brauninger A, Kuppers R, Spieker T, Siebert R, Strickler JG, Schlegelberger B, Rajewsky K, Hansmann ML: Molecular analysis of single B cells from T cell-rich B cell lymphoma shows the derivation of the tumor cells from mutating germinal center B cells and exemplifies means by which immunoglobulin genes are modified in germinal center B cells.  Blood 93:2679-2687, 1999. 

73.  Brauninger A, Hansmann ML, Strickler JG, Dummer R, Burg G, Rajewsky K, Kuppers R: Identification of common germinal-center B-cell precursors in two patients with both Hodgkin’s disease and non-Hodgkin’s lymphoma. N Engl J Med 340;1239-1247, 1999. 

74.  *Cataldo KA, Jalal SM, Law ME, Ansell SM, Inwards DJ, Fine M, Arber DA, Pulford KA, Strickler JG:  Detection of t(2;5) in anaplastic large cell lymphoma.  Comparison of immunohistochemical studies, FISH, and RT-PCR in paraffin-embedded tissue.  Am J Surg Pathol 23:1386-1392, 1999. 

75.  Kurth J, Spieker T, Wustrow J, Strickler JG, Hansmann ML, Rajewsky K, Kuppers R:  EBV-infected B cells in infectious mononucleosis:  viral strategies for spreading in the B cell compartment and establishing latency. Immunology 13:485-495, 2000. 

76.  Reinartz JJ, McCormick SR, Ikier DM, Mellgen AM, Bonham SC, Strickler JG, Mendiola JR:  Immunoglobulin heavy-chain gene rearrangement studies by Southern blot using DNA extracted from formalin fixed paraffin embedded tissue.  Molecular Diagnosis 5:227-233, 2000. 

77.  Kuppers R, Sousa A, Baur AS, Strickler JG, Rajewsky K, Hansmann ML:  Common germinal-center B cell origin of the malignant cells in two composite lymphomas, involving classical Hodgkin’s disease and either follicular lymphoma or B-CLL.  Molecular medicine 7:285-292, 2001. 

78.  Kurtin PJ, Myers JL, Adlakha H, Strickler JG,  Lohse C, Pankratz VS, Inwards DJ:  Pathologic and clinical features of primary pulmonary extranodal marginal zone B-cell lymphoma of MALT type.  Am J Surg Pathol 25:997-1008, 2001.