LESLIE K. DIAZ, JR, MD

  Abbott Northwestern Hospital Laboratory

BREAST-RELATED PUBLICATIONS

• Diaz LK, Wiley EL, Venta LA. Are malignant cells displaced by large-gauge needle core biopsy of the breast? AJR. American Journal of Roentgenology 1999;173:1303-1313.

• Diaz LK, Wiley EL, Morrow M. Expression of epithelial mucins MUC1, MUC2, and MUC3 in ductal carcinoma in situ of the breast. The Breast Journal 2001;7:40-45.

• Wiley EL, Diaz LK, Badve S, Morrow M. Effect of time interval on residual disease in breast cancer. American Journal of Surgical Pathology 2003;27:194-198.

• Diaz LK, Hunt K, Ames F, Meric F, Kuerer H, Babiera G, Ross M, Singletary E, Middleton LP, Symmans WF, Krishnamurthy S, Sahin A, Sneige N, Gilcrease MZ. Histologic localization of axillary sentinel lymph node metastases in breast cancer. American Journal of Surgical Pathology 2003;27:385-389.

• Diaz LK, Zhou X, Welch K, Sahin A, Gilcrease MZ. Chromogenic in-situ hybridization for alpha6beta4 integrin in breast cancer: correlation with protein expression. Journal of Molecular Diagnostics 2004;6:10-15.

• Diaz LK, Gilcrease MZ. Histologic localization of sentinel lymph node metastases in breast cancer (Authors’ reply). American Journal of Surgical Pathology 2004;28:275-276.

• Diaz LK, Sahin A, Sneige N. Interobserver agreement for estrogen receptor immunohistochemical analysis in breast cancer: a comparison of manual and computer-assisted scoring methods. Annals of Diagnostic Pathology 2004;8:23-27.

• Diaz LK, Gupta R, Kidwai N, Sneige N, Wiley EL. The use of TMA for interlaboratory validation of FISH testing for detection of HER2 gene amplification in breast cancer. Journal of Histochemistry and Cytochemistry 2004;52:501-507.

• Wiley EL, Diaz LK. High quality HER-2 testing: setting a standard for oncologic biomarker assessment. JAMA 2004;291:2019-2020.

• Diaz LK, Sneige N. Estrogen receptor analysis for breast cancer: current issues and keys to increasing testing accuracy. Advances in Anatomic Pathology 2005;12:10-19.

• Moncrief RM, Nayar R, Diaz LK, Staradub VL, Morrow M, Khan SA. A comparison of conventional surgical excision in women with spontaneous nipple discharge. Annals of Surgery 2005;241:575-581.

• Diaz LK, Zhou X, Wright ET, Cristofanilli M, Smith T, Yang Y, Sneige N, Sahin A, Gilcrease MZ. CD44 expression is associated with increased survival in node-negative invasive breast carcinoma. Clinical Cancer Research 2005;11:3309-3314.

• Rodriquez N, Diaz LK, Wiley EL. Predictors of residual disease in re-excisions for lumpectomies with close margins (<0.1 cm). Clinical Breast Cancer 2005;6:169-172. 

• Manders JB, Barke LD, Wahl A, Wolfman JA, Small W, Keeney KM, Gradishar WJ, Diaz LK. Primary sarcoma of the breast: a diagnostic dilemma. Breast Cancer Online 2005:8:6.

• Diaz LK, Cristofanilli M, Zhou X, Welch K, Smith TL, Sneige N, Sahin A, Gilcrease MZ. Beta4 integrin subunit gene expression correlates with tumor size and nuclear grade in early breast cancer. Modern Pathology 2005;18:1165-1175.

• Moyano JV, Evans J, Chen F, Lu M, Werner ME, Yehiely F, Diaz LK, Turbin D, Karaca G, Wiley EL, Nielsen TO, Perou CM, Cryns VL. αB-Crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer. Journal of Clinical Investigation 2006;116:261-270.

• Schafernak KT, Policarpio-Nicolas MLC, Wiley EL, Diaz LK. A 59-year-old with a spindle cell lesion of the breast. Low-grade (fibromatosis-like) spindle cell carcinoma of the breast.  Archives of Pathology & Laboratory Medicine 2006;130:e81-83.

• Gokhale S, Rosen DG, Sneige N, Diaz LK, Resetkova E, Sahin A, Liu J, Albarracin CT. Assessment of two automated systems in evaluation of estrogen receptor status in breast carcinoma. Applied Immunohistochemistry & Molecular Morphology (In press).

• Sitterding SM, Wiseman WR, Schiller CL, Luan C, Moyano JV, Chen F, Wiley EL, Cryns VL, Diaz LK. αB-crystallin: a novel marker of invasive basal-like and metaplastic breast carcinomas. Annals of Diagnostic Pathology (In press).   

Abstracts (selected):

• Diaz LK, Sahin A, Sneige N. Immunohistochemical detection of estrogen receptor in breast cancer: a laboratory quality improvement study. Modern Pathology 16:27A, 2003.

• Clatch R, Diaz LK, Wang D. Correlation of Cell Analysis QCA imaging system with ER quantification by radioimmunoassay and manual immunohistochemistry. Breast Cancer Research and Treatment 82:S144, 2003.

• Huo L, Kashireddy P, Rao MS, Diaz LK. Peroxisome proliferator-activated receptor gamma expression in invasive breast cancer. Modern Pathology 17:35A, 2004.

• Diaz LK, Huo L, Herm J, Wang D, Clatch R. Rapid and low cost image analysis for tissue microarray immunohistochemistry. Modern Pathology 17:353A, 2004.

• Diaz LK, Huo L, Gupta A, Kidwai N, Sneige N, Wiley EL. Comparison of the effects of alcoholic formalin fixation to standard formalin fixation on estrogen receptor analysis by immunohistochemistry in breast cancer. Modern Pathology 17:346A, 2004.

• Gong Y, Diaz L, Tarco E, Wiley E, Sneige N. Comparison of fluorescence in situ hybridization (FISH) and chromogenic in situ hybridization (CISH) in the evaluation of HER-2 status. Modern Pathology 17:32A, 2004.

• Gokhale S, Sneige N, Diaz LK, Rosen D, Resetkova E, Sahin A, Albarracin CT. Assessment of two automated systems of imaging technology in evaluation of estrogen receptor status in invasive carcinoma of breast. Modern Pathology 17:32A, 2004.

• Gupta A, Diaz LK, Wiley EL. Atypical duct hyperplasia and lobular neoplasia diagnosed by core needle biopsy: incidence of up staging to DCIS and invasive carcinoma. Modern Pathology 17:123A, 2004.

• Kulkarni S, Diaz L, Wiley E, Bhandare D, Morrow M, Khan SA. High cyclooxygenase-2 (COX-2) and low peroxisome proliferator-activated receptor γ (PPARγ) expression predict ipsilateral 2004. Breast Cancer Research and Treatment 88:S102, 2004.

• Policarpio-Nicolas ML, Schafernak KT, Diaz LK, Kidwai N, Wiley EL. Epidermal growth factor receptor expression in high grade invasive mammary carcinoma. Modern Pathology 18:46A, 2005.

• Policarpio-Nicolas ML, Wiley EL, Kulkarni S, Papavero V, Khan SA, Diaz LK. Telomere length changes in DCIS and recurrent disease. Modern Pathology 18:47A, 2005.

• Sitterding SM, Wiseman WR, Schiller CL, Watkin WG, Luan C, Wiley EL, Moyano JV, Cryns VL, Diaz LK. alphaB-Crystallin: a novel marker for metaplastic and basal-like breast cancers. Modern Pathology 19, 2006

• Wiseman WR, Sitterding SM, Schiller CL, Watkin WG, Luan C, Wiley EL, Gilcrease MZ, Diaz LK. Expression of alpha6beta4 integrin and genes upregulated by alpha6beta4 integrin activation in basal/myoepithelial-like breast cancer. Modern Pathology 19, 2006

• Schiller CL, Watkin WG, Wiseman WR, Sitterding SM, Sikka K, Wiley EL, Diaz LK. Lack of EGFR gene amplification for metaplastic and basal-like breast cancers measured using dual probe FISH. Modern Pathology 19, 2006

• Schiller CL, Wiseman WR, Luan C, Watkin WG, Sitterding SM, Wiley EL, Gilcrease MZ, Diaz LK. Laminin-5 expression in basal/myoepithelial-like mammary carcinoma. Modern Pathology 19, 2006

• Diaz LK, Luan C, Zhou X, Gilcrease MZ. Adhesion-independent clustering of alpha6beta4 integrin in breast cancer cells increases gene expression of non-muscle myosin and cdc42.  AACR Annual Meeting, Washington DC, 2006.